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While about 15-35% of surgical patients did not reach their goal weight loss, usually due to advanced age, previous abdominal surgery, hypertension or depression) the majority succeeded, according to a 2020 BMC Endocrine Disorders Journal that followed 130 patients for a year after surgery

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Although preliminary findings indicate that GLP-1Ra causes modest BMD reduction and enhances bone remodeling, favoring resorption similar to the effects of calorie restriction, further research is needed

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PMC 8399837

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Impact of Managed Care on Cancer Trial Enrollment

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